Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 38, Issue 12, Pages 621-639Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2013.09.004
Keywords
SET domain-containing proteins; histone lysine methylation; non-histone substrates
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Funding
- National Institutes of Health [R01CA150265, R01CA89455, R01GM069905]
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SET domain-containing proteins belong to a group of enzymes named after a common domain that utilizes the cofactor S-adenosyl-L-methionine (SAM) to achieve methylation of its substrates. Many SET domain-containing proteins have been shown to display catalytic activity towards particular lysine residues on histones, but emerging evidence also indicates that various nonhistone proteins are specifically targeted by this clade of enzymes. Here, we summarize the most recent findings on the biological functions of the major families of SET domain-containing proteins catalyzing the methylation of histones 3 on lysines 4, 9, 27, and 36 (H3K4, H3K9, H3K27, and H3K36) and histone 4 on lysine 20 (H4K20), as well as enzymes that have been reported to modify nonhistone substrates.
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