Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 38, Issue 6, Pages 321-330Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2013.03.002
Keywords
DNA repair; poly(ADP-ribose) polymerase (PARP); double-strand break; UV-induced DNA damage; nucleotide excision repair; homologous recombination; non-homologous end-joining
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Funding
- Netherlands Organization for Scientific Research
- Federation of European Biochemical Societies
- Human Frontiers Science Program
- Dutch Cancer Society
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Distinct types of DNA damage elicit signaling and repair pathways that counteract the adverse effect of DNA lesions to maintain genome stability. The negatively charged polymer poly(ADP-ribose), which is catalyzed by poly(ADP-ribose) polymerase (PARP) enzymes, is a post-translational modification that serves as a chromatin-based platform for the recruitment of a variety of repair factors and chromatin-remodeling enzymes. Recent work implicates PARP3 in the efficient joining of DNA double-strand breaks during non-homologous end-joining (NHEJ), whereas PARP1 modulates the repair of UV-induced DNA lesions. Here we discuss emerging roles of PARP enzymes in mechanistically distinct DNA repair pathways and highlight unresolved issues and questions for future research.
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