Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 38, Issue 8, Pages 403-411Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2013.06.002
Keywords
quality control; ribosome; stalling; tmRNA; translation; trans-translation
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Funding
- Agence Nationale pour la Recherche [ANR-08JCJC-0027-01, ANR-09-MIE]
- Institut Universitaire de France
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In bacteria, the main quality control mechanism for rescuing ribosomes that have arrested during translation is trans-translation, performed by transfer-mRNA (tmRNA) associated with small protein B (SmpB). Intriguingly, this very elegant mechanism is not always necessary to maintain cell viability, suggesting the existence of alternatives. Other rescue systems have recently been discovered, revealing a far more complicated story than expected. These include the alternative ribosome rescue factors ArfA and ArfB, the elongation factors EF4 and EF-P, the peptidyl-tRNA hydrolase Pth, and several protein synthesis factors. These discoveries make it possible to describe a large network of factors dedicated to ribosome rescue, thus ensuring cell survival during stresses that induce ribosome stalling.
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