Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 38, Issue 10, Pages 477-479Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2013.08.004
Keywords
MEX-3; RNA-binding protein; post-transcriptional regulation; CDX2; development; carcinogenesis
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RNA-binding proteins of the evolutionarily-conserved MEX-3 family are mediators of post-transcriptional regulation in different organisms. Recent studies highlight their involvement in diverse physiological settings, including the maintenance of a balance between stem cell self-renewal and differentiation. Here, we draw attention to their putative role in tissue homeostasis and disease, particularly cancer.
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