Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 37, Issue 11, Pages 466-476Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2012.08.001
Keywords
chromatin; epigenetics; histone; heterochromatin; senescence
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Funding
- American Federation for Aging Research (AFAR)
- Karlseder laboratory by the National Institutes of Health (NIH) [CA014195, GM087476]
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During embryogenesis, the establishment of chromatin states permits the implementation of genetic programs that allow the faithful development of the organism. However, these states are not fixed and there is much evidence that stochastic or chronic deterioration of chromatin organization, as correlated by transcriptional alterations and the accumulation of DNA damage in cells, occurs during the lifespan of the individual. Whether causal or simply a byproduct of macromolecular decay, these changes in chromatin states have emerged as potentially central conduits of mammalian aging. This review explores the current state of our understanding of the links between chromatin organization and aging.
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