Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 36, Issue 2, Pages 65-77Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2010.09.006
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Funding
- National Institutes of Health [GM19301]
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Eukayotic protein kinases evolved as a family of highly dynamic molecules with strictly organized internal architecture. A single hydrophobic F-helix serves as a central scaffold for assembly of the entire molecule. Two nonconsecutive hydrophobic structures termed spines anchor all the elements important for catalysis to the F-helix. They make firm, but flexible, connections within the molecule, providing a high level of internal dynamics of the protein kinase. During the course of evolution, protein kinases developed a universal regulatory mechanism associated with a large activation segment that can be dynamically folded and unfolded in the course of cell functioning. Protein kinases thus represent a unique, highly dynamic, and precisely regulated set of switches that control most biological events in eukaryotic cells.
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