Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 36, Issue 8, Pages 397-404Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2011.04.003
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Funding
- NIGMS NIH HHS [R01 GM084034-04, R01 GM084034, R01 GM067719-09, R01 GM067719] Funding Source: Medline
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With recent advances in microarrays and sequencing it is now relatively straightforward to compare pre-mRNA splicing patterns in different cellular conditions on a genome-wide scale. Such studies have revealed extensive changes in cellular splicing programs in response to stimuli such as neuronal depolarization, DNA damage, immune signaling and cellular metabolic changes. However, for many years our understanding of the signaling pathways responsible for such splicing changes was greatly lacking. Excitingly, over the past few years this gap has begun to close. Recent studies now suggest notable trends in the mechanisms that link cellular stimuli to downstream alternative splicing events. These include regulated synthesis or degradation of splicing factors, differential protein protein interactions, altered nuclear translocation and changes in transcription elongation.
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