Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 36, Issue 9, Pages 457-469Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2011.06.003
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Funding
- National Institutes of Health [HL16037, HL70631]
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beta-Arrestins, originally discovered to desensitize activated seven transmembrane receptors (7TMRs; also known as G-protein-coupled receptors, GPCRs), are now well established mediators of receptor endocytosis, ubiquitylation and G protein-independent signaling. Recent global analyses of beta-arrestin interactions and beta-arrestin-dependent phosphorylation events have uncovered several previously unanticipated roles of beta-arrestins in a range of cellular signaling events. These findings strongly suggest that the functional roles of beta-arrestins are much broader than currently understood. Biophysical studies aimed at understanding multiple active conformations of the 7TMRs and the beta-arrestins have begun to unravel the mechanistic basis for the diverse functional capabilities of beta-arrestins in cellular signaling.
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