Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 36, Issue 11, Pages 585-592Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2011.07.005
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Funding
- NIH [RO1GM069900, 1R21NS0676601, 5R00GM080447]
- NSF [1020739]
- Welch Foundation [AU-1773]
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1020739] Funding Source: National Science Foundation
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Defective mRNAs are degraded more rapidly than normal mRNAs in a process called mRNA surveillance. Eukaryotic cells use a variety of mechanisms to detect aberrations in mRNAs and a variety of enzymes to preferentially degrade them. Recent advances in the field of RNA surveillance have provided new information regarding how cells determine which mRNA species should be subject to destruction and novel mechanisms by which a cell tags an mRNA once such a decision has been reached. In this review, we highlight recent progress in our understanding of these processes.
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