Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 35, Issue 3, Pages 135-144Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2009.10.005
Keywords
-
Categories
Funding
- German Research Foundation (DFG) [BR 3706/1-1]
- Austrian Science Fund (FWF) [T-414-809, S-9304-805]
- European Commission
Ask authors/readers for more resources
Neurodegeneration is characterized by the disease-specific loss of neuronal activity, culminating in the irreversible destruction of neurons. Neuronal cell death can proceed via distinct subroutines such as apoptosis and necrosis, but the underlying molecular mechanisms remain poorly understood. Saccharomyces cerevisiae is an established model for programmed cell death, characterized by distinct cell death pathways conserved from yeast to mammals. Recently, yeast models for several major classes of neurodegeneration, namely alpha-synucleinopathies, polyglutamine disorders, beta-amyloid diseases, tauopathies, and TDP-43 proteinopathies, have been established. Heterologous expression of the human proteins implicated in these disorders has unraveled important insights in their detrimental function, pointing to ways in which yeast might advance the mechanistic dissection of cell death pathways relevant for human neurodegeneration.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available