Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 35, Issue 2, Pages 101-108Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2009.09.001
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Funding
- NCI NIH HHS [R01 CA089239-11, R01 CA089239, R01 CA100109-08, R01 CA092312-11, R01 CA100109-09, R01 CA092312-10, R01 CA089239-10, R01 CA100109, R01 CA092312] Funding Source: Medline
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The remarkably coordinated nature of the DNA damage response pathway relies on numerous mechanisms that facilitate the assembly of checkpoint and repair factors at DNA breaks. Post-translational modifications on and around chromatin have critical roles in allowing the timely and sequential assembly of DNA damage responsive elements at the vicinity of DNA breaks. Notably, recent advances in forward genetics and proteomics-based approaches have enabled the identification of novel components within the DNA damage response pathway, providing a more comprehensive picture of the molecular network that assists in the detection and propagation of DNA damage signals.
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