Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 35, Issue 4, Pages 189-198Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2009.11.005
Keywords
-
Categories
Funding
- Studienstiftung des deutschen Volkes
- DFG [SFB 749]
- Fonds der chemischen Industrie
- NIH [GM54068]
- Cancer Center [CA21765]
- American Lebanese Syrian Associated Charities of Saint Jude Children's Research Hospital
Ask authors/readers for more resources
B cells use unconventional strategies for the production of a seemingly unlimited number of antibodies from a very limited amount of DNA. These methods dramatically increase the likelihood of producing proteins that cannot fold or assemble appropriately. B cells are therefore particularly dependent on 'quality control' mechanisms to oversee antibody production. Recent in vitro experiments demonstrate that Ig domains have evolved diverse folding strategies ranging from robust spontaneous folding to intrinsically disordered domains that require assembly with their partner domains to fold; in vivo experiments reveal that these different folding characteristics form the basis for cellular checkpoints in Ig transport. Taken together, these reports provide a detailed understanding of how B cells monitor and ensure the functional fidelity of Ig proteins.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available