Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 34, Issue 10, Pages 520-531Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2009.06.004
Keywords
-
Categories
Funding
- Cure Cancer Australia Fellowship
- University of Queensland Post-doctoral Fellowship
Ask authors/readers for more resources
ATP-binding cassette (ABC) transporters form one of the largest and most ancient of protein families. ABC transporters couple hydrolysis of ATP to vectorial translocation of diverse substrates across cellular membranes. Many human ABC transporters are medically important in causing, for example, multidrug resistance to cytotoxic drugs. Seven complete prokaryotic structures and one eukaryotic structure have been solved for transporters from 2002 to date, and a wealth of research is being conducted on and around these structures to resolve the mechanistic conundrum of how these transporters couple ATP hydrolysis in cytosolic domains to substrate translocation through the transmembrane pore. Many questions remained unanswered about this mechanism, despite a plethora of data and a number of interesting and controversial models.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available