Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 34, Issue 12, Pages 640-647Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2009.07.008
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Funding
- La Ligue contre le Cancer
- CNRS
- Agence Nationale de la Recherche [AN-R-07-BLAN-0093]
- National Institutes of Health [RO1GM 046454]
- Houston Endowment, Inc
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BTG/TOB factors are a family of antiproliferative proteins whose expression is altered in numerous cancers. They have been implicated in cell differentiation, development and apoptosis. Although proposed to affect transcriptional regulation, these factors interact with CAF1, a subunit of the main eukaryotic deadenylase, and with poly(A)-binding-proteins, strongly suggesting a role in post-transcriptional regulation of gene expression. The recent determination of the structures of BTG2, TOB1N-terminal domain (TOB1N138) and TOB1N138-CAF1 complexes support a role for BTG/TOB proteins in mRNA deadenylation, a function corroborated by recently published functional characterizations. We highlight molecular mechanisms by which BTG/TOB proteins influence deadenylation and discuss the need for a better understanding of BTG/TOB physiological functions.
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