Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 33, Issue 3, Pages 141-150Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2007.12.003
Keywords
-
Categories
Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R56AI033600] Funding Source: NIH RePORTER
- NIAID NIH HHS [R56 AI033600] Funding Source: Medline
Ask authors/readers for more resources
Cytoplasmic RNA structures such as stress granules (SGs) and processing bodies (PBs) are functional byproducts of mRNA metabolism, sharing substrate mRNA, dynamic properties and many proteins, but also housing separate components and performing independent functions. Each can exist independently, but when coordinately induced they are often tethered together in a cytosolic dance. Although both self-assemble in response to stress-induced perturbations in translation, several recent reports reveal novel proteins and RNAs that are components of these structures but also perform other cellular functions. Proteins that mediate splicing, transcription, adhesion, signaling and development are all integrated with SG and PB assembly. Thus, these ephemeral bodies represent more than just the dynamic sorting of mRNA between translation and decay.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available