Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 33, Issue 8, Pages 356-359Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2008.05.003
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Phosphorylation of the protein kinase Akt at Ser473 is a key regulatory event in the induction of cellular survival mechanisms. A new study provides a novel mechanism for Akt activation. In cells and mice exposed to DNA-damaging insults, Ser473 phosphorylation is mediated by the DNA-dependent protein kinase at sites of DNA double-strand breaks. This event triggers the induction of a transcriptional program that promotes survival in response to DNA damage.
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