Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 33, Issue 3, Pages 132-140Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2007.11.003
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In transmissible spongiform encephalopathies, the infectious material consists chiefly of a protein, the scrapie prion protein PrPSc, that carries no genetic coding material; however, prions are likely to have accomplices that chaperone their activity and promote the conversion of the cellular prion protein PrPC into the disease-causing isoform (PrPSc). Recent studies from several laboratories indicate that PrPC recognizes many nucleic acids (NAs) with high affinities, and we correlate these findings with a possible pathophysiological role for this interaction. Thus, of the chaperones, NA is the most likely candidate for prions. The participation of NAs in prion propagation opens new avenues for developing new diagnostic tools and therapeutics to target prion diseases, as well as for understanding the function of PrPC, probably as a NA chaperone.
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