Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 33, Issue 12, Pages 565-568Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2008.09.005
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Funding
- NCI NIH HHS [P01 CA120964, P01 CA120964-01A1] Funding Source: Medline
- NIDDK NIH HHS [R01 DK080425, R01 DK080425-02] Funding Source: Medline
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mTOR (mammalian target of rapamycin) is a highly conserved nutrient-responsive regulator of cell growth that is found in all eukaryotes. The mechanism by which amino acids signal to mTOR has remained one of the largest outstanding questions in the field. Two recent complimentary studies provide compelling evidence that the Rag family of small GTPases is both necessary and sufficient to transmit a positive signal from amino acids to mTOR.
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