Antibacterial Networks Based on Isosorbide and Linalool by Photoinitiated Process

In this study, we used photo-induced thiol-ene reactions to design bio-based cross-linked networks from diallyl derivative isosorbide, a crude monoterpene as linalool and a trithiol. The aim of this study is to prepare new antibacterial UV-cured networks by using a thiol-ene formulation with covalent immobilization of monoterpenes as antibacterial agents and without any organic solvent thanks to the solvent-like properties of linalool. The challenge was to demonstrate the advantage of using linalool as a chemical platform molecule and, at the same time, as an antibacterial agent. The incorporation of linear linalool to the rigid isosorbide moiety generates flexible networks. Different networks were prepared by varying the mass ratio of linalool (from 0 to 100% w/w) mixed into the coating and then characterized. Their antibacterial activities were investigated in vitro against two pathogenic bacteria strains: Escherichia coli and Staphylococcus aureus. The results have shown a promising antiadherence for S. aureus without any diffusion of linalool that will allow potential applications of terpenes coatings for antibacterial adhesion.