Journal
TRANSPLANTATION PROCEEDINGS
Volume 46, Issue 10, Pages 3511-3514Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.transproceed.2014.06.079
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Purpose. To investigate CD152 and PD-1 expression on T lymphocytes and the function of CD152- and PD-1 positive CD8 T cells in human acute liver allograft rejection. Materials and methods. Sixty-three patients undergoing liver transplantation were enrolled in this study, including 26 cases with acute allograft rejection (Gr-AR) and 37 cases with stable allograft liver function (Gr-SF). The expression of CD152 and PD-1 on T lymphocytes and the expression of granzyme and perforin on CD152- and PD-1 positive CD8 T cells in peripheral blood were analyzed using flow cytometry. Results. The peripheral CD4/CD8 ratio in Gr-AR was significantly lower than that in Gr-SF (P < .01). The expression of CD152 and PD-1 on CD8 and CD4 T cells was significantly lower in Gr-AR than in Gr-SF (all P < .01). The expression of granzyme B and perforin was significantly higher in Gr-AR than in Gr-SF (P < .01). Conclusions. Down-regulation of the expression of negative costimulatory molecules such as CD152 and PD-1 on CD8 T cells may be associated with human acute liver allograft rejection.
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