Journal
TRANSPLANTATION PROCEEDINGS
Volume 42, Issue 9, Pages S7-S12Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.transproceed.2010.07.040
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Funding
- NCI NIH HHS [CA125550, R01 CA125550] Funding Source: Medline
- NIAAA NIH HHS [R01 AA013913, AA13913] Funding Source: Medline
- NIDDK NIH HHS [R01 DK062987, DK 61688, T32DK07760, T32 DK007760, R01 DK055001, DK62987, DK55001, R01 DK061688] Funding Source: Medline
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Every year in the United States, 5000 renal transplant recipients start or restart dialysis because of the unusual propensity of these allografts to develop interstitial fibrosis and tubular atrophy (IF/TA) Although IF/TA often follows one or more identifiable events, our capacity to specifically treat, prevent, or even detect IF/TA at an early stage is poor These limitations are largely related to our lack of adequate tools to assess graft failure over time Data accumulated over the past 5 years have demonstrated that tubular epithelial cells may react to certain fibrogenic stimuli to engage in the process of epithelial-to-mesenchymal transition (EMT) In this review, we highlight the current view of EMT with a focus on both its role in the context of renal transplantation and the potential for utilizing markers of EMT to identify patients undergoing early IF/TA
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