Journal
TRANSPLANTATION PROCEEDINGS
Volume 41, Issue 5, Pages 1630-1633Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.transproceed.2009.01.091
Keywords
-
Categories
Funding
- Ankara University Research Foundation [2001-08-03-028]
- Ankara University Biotechnology Institute [2001-K-120-240(35)]
- TUBITAK [SBAG-AYD-438]
Ask authors/readers for more resources
Renal transplantation is widely used to treat patients with end-stage renal disease. Atherosclerosis is an important posttransplantation risk factor for renal transplant recipients. Subsequent to transplantation low-density lipoprotein (LDL) particles become susceptible to oxidative modification, which results in atherosclerosis. Therefore, the aim of our study was to investigate differences in the susceptibility of LDL particles to oxidation by analyzing LDL fatty acid levels among renal transplant recipients. The changes in lag phases and fatty acid levels of LDL were observed over 4 months among renal transplant recipients treated with Cyclosporine (CsA; n = 7) or Tacrolimus (FK-506; n = 9). We also analyzed cholesterol and triglyceride levels of patients and healthy controls. The lag phase at the 60th day after transplantation was significantly shorter than the results either before transplantation or among control subjects. In conclusion, a similar decrease in lag phase was observed in both above groups, but the FK-506-treated group showed a better lipid profile than the CsA-treated group.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available