Journal
TRANSPLANTATION
Volume 97, Issue 11, Pages 1091-1099Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/TP.0000000000000072
Keywords
Aging; Transplantation; Injury; Repair
Categories
Funding
- National Institutes of Health [RO1AG039449]
- Carlos Slim Foundation de la Salud
- Transplantation Society Basic Science Research Exchange Fellowship
- Michael van Vloten Fund
- European Society for Surgical Research
- Erasmus MC Department of Surgery stipend
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Donor organ scarcity remains a significant clinical challenge in transplantation. Older organs, increasingly utilized to meet the growing demand for donor organs, have been linked to inferior transplant outcomes. Susceptibility to organ injury, reduced repair capacity, and increased immunogenicity are interrelated and impacted by physiological and pathological aging processes. Insights into the underlying mechanisms are needed to develop age-specific interventional strategies with regards to organ preservation, immunosuppression, and allocation. In this overview, we summarize current knowledge of injury and repair mechanisms and the effects of aging relevant to transplantation.
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