Journal
TOXINS
Volume 7, Issue 1, Pages 156-169Publisher
MDPI
DOI: 10.3390/toxins7010156
Keywords
maize RIP; anti-HIV; animal model; viral load
Categories
Funding
- Key Scientific and Technological Program of China [2012ZX10001-006, 2013ZX10001-002, 2014ZX10005-002]
- National Basic Research Program of China [2012CBA01305]
- NSFC [81273251, 81172876]
- Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan
- CAS [KJZD-EW-L10-02]
- Research Fund for the Control of Infectious Diseases [10090452]
Ask authors/readers for more resources
Ribosome inactivating proteins (RIPs) inhibit protein synthesis by depurinating the large ribosomal RNA and some are found to possess anti-human immunodeficiency virus (HIV) activity. Maize ribosome inactivating protein (RIP) has an internal inactivation loop which is proteolytically removed for full catalytic activity. Here, we showed that the recombinant active maize RIP protected chimeric simian-human immunodeficiency virus (SHIV) 89.6-infected macaque peripheral blood mononuclear cells from lysis ex vivo and transiently reduced plasma viral load in SHIV89.6-infected rhesus macaque model. No evidence of immune dysregulation and other obvious side-effects was found in the treated macaques. Our work demonstrates the potential development of maize RIP as an anti-HIV agent without impeding systemic immune functions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available