Journal
TOXINS
Volume 7, Issue 11, Pages 4730-4744Publisher
MDPI
DOI: 10.3390/toxins7114730
Keywords
natural killer cells; dendritic cells; experimental autoimmune encephalomyelitis; 1,25-Dihydroxyvitamin D-3; monomethyl fumarate; myelin proteolipid protein
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Experimental autoimmune encephalomyelitis (EAE) is a CD4(+) T cell mediated inflammatory demyelinating disease that is induced in mice by administration of peptides derived from myelin proteins. We developed EAE in SJL mice by administration of PLP139-151 peptide. The effect of treating these mice with 1,25-Dihydroxyvitamin D-3 (vitamin D-3), or with monomethyl fumarate (MMF) was then examined. We observed that both vitamin D-3 and MMF inhibited and/or prevented EAE in these mice. These findings were corroborated with isolating natural killer (NK) cells from vitamin D-3-treated or MMF-treated EAE mice that lysed immature or mature dendritic cells. The results support and extend other findings indicating that an important mechanism of action for drugs used to treat multiple sclerosis (MS) is to enhance NK cell lysis of dendritic cells.
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