Journal
TRANSPLANTATION
Volume 93, Issue 11, Pages 1075-1085Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/TP.0b013e31824810e6
Keywords
Cytomegalovirus (CMV); Mammalian target of rapamycin (mTOR) inhibitors; Sirolimus; Everolimus; Anti-CMV mechanism of action
Categories
Funding
- Bristol-Myers Squibb
- Pfizer
- Novartis
- Astellas
- Lifecycle Biopharma
- Roche
- CKD
- Wyeth
- Genentech
- Genzyme
- Novartis Pharma AG
Ask authors/readers for more resources
Cytomegalovirus (CMV) infection and disease are major complications in the renal transplant recipient. The occurrence of CMV is associated with acute rejection, allograft dysfunction, significant end-organ disease, and mortality. Several clinical studies have indicated that the use of certain immunosuppressive drugs can delay the reconstitution of CMV-specific cell-mediated immune responses, thereby leading to uncontrolled CMV replication. Accumulating evidence indicates, however, that the use of the mammalian target of rapamycin (mTOR) inhibitors, sirolimus, and everolimus, may decrease the incidence and severity of CMV infection in renal transplant recipients. The purpose of this article is to review CMV infection data from randomized clinical trials that investigated the use of sirolimus- and everolimus-based treatment regimens in de novo renal transplantation. The mTOR inhibitor clinical trials included were primarily identified using biomedical literature database searches, with additional studies added at the authors' discretion. This review will summarize these studies to discuss whether mTOR inhibitor-based immunosuppressive therapy can reduce the magnitude of CMV-related complications in the de novo renal transplantation setting.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available