Journal
TRANSPLANTATION
Volume 90, Issue 9, Pages 945-948Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/TP.0b013e3181f5c3de
Keywords
Th17; Transplantation; Tolerance
Categories
Funding
- National Institutes of Health [R01 AI061469, R01 HL070613, T32 AI078892]
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The discovery of Th17 cells has revealed a novel pathway of T-cell maturation. As with Th1 and Th2 lineages, Th17 cells promote graft pathology. However, a growing body of evidence indicates that Th17 cells may exhibit resistance to current methods of immunosuppression. Identification of this lineage provides an additional and challenging target for promoting graft acceptance.
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