Journal
TRANSPLANTATION
Volume 87, Issue 4, Pages 457-466Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/TP.0b013e3181963ad3
Keywords
Artificial liver support; Bioartificial liver support; Fulminant liver failure; Hepatocyte transplantation
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Shortage of organ donors limits the number of possible liver transplantations. Alternative therapies for treatment of liver failure are currently being developed: (i) extracorporeal artificial liver devices; (ii) bioartificial liver devices using hepatocytes; and (iii) hepatocyte transplantation. The objective of these strategies is to bridge patients with liver failure until a Suitable liver allograft is obtained for transplantation or the patient's own liver regenerates sufficiently to resume normal function. In this review, we discuss these strategies and summarize the Current status of clinical experience.
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