Journal
TRANSPLANTATION
Volume 86, Issue 10, Pages 1340-1348Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/TP.0b013e3181891d8b
Keywords
Antigen presentation; Inflammation; Leukocyte; Lymphocyte; Antibody; Complement
Categories
Funding
- British Heart Foundation Funding Source: Medline
- NHLBI NIH HHS [HL051014, HL070295, R01 HL062188, R01 HL036003-23A1, R01 HL036003, P01 HL070295-08, R01 HL051014, HL062188, R01 HL051014-15, P01 HL070295, R01 HL062188-09, R37 HL036003, HL036003] Funding Source: Medline
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in organ transplantation, blood borne cells and macromolecules (e.g., antibodies) of the host immune system are brought into direct contact with the endothelial cell lining of graft vessels. In this location, graft endothelial cells play several roles in allograft rejection, including the initiation of rejection responses by presentation of alloantigen to circulating T cells; the development of inflammation and thrombosis; and as targets of injury and agents of repair.
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