Journal
TRANSPLANTATION
Volume 86, Issue 11, Pages 1485-1491Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/TP.0b013e31818f3d2a
Keywords
Regulatory T cells; Rejection; Tolerance; Diagnostic value
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Funding
- Genzyme Innovative program award
- Medical Research Council [G0600698B] Funding Source: researchfish
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FOXP3 has emerged as the most suitable marker for Treg and has been studied in both experimental and clinical transplantation. Biopsy samples have been stained for FOXP3(+) cells whereas FOXP3 messenger RNA levels have been measured in blood and urine samples after transplantation. Although not unanimous, some studies have suggested that FOXP3 is associated with better outcome and can also serve as a marker of rejection. Routine staining of FOXP3(+) cells in biopsy samples and FOXP3 messenger RNA levels in urine of kidney transplant patients may determine each patient's immunological profile, enabling less immunosuppression to be given to those at lower risk.
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