Journal
TRANSPLANT INTERNATIONAL
Volume 26, Issue 3, Pages 242-253Publisher
WILEY
DOI: 10.1111/tri.12013
Keywords
aging; immunosenescence; immunosuppression; organ allocation; organ transplantation; transplant outcome
Categories
Funding
- NIH [AG039449]
- Instituto Carlos Slim de la Salud
- Charite Foundation
- International Academy of Life Sciences/German Academic Exchange Service
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Aging affects all compartments of the immune response and has a major impact on transplant outcome and organ quality. Although clinical trials in the aging transplant population remain rare, our current understanding of immunosenescence provides a basis for an age-adapted immunosuppression and organ allocation with the goal to optimize utilization and to improve outcomes in older recipients. From a more general perspective, understanding the mechanisms and consequences of immunosenescence will have a broad impact on immune therapies in and beyond transplantation.
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