Journal
TRANSPLANT INTERNATIONAL
Volume 25, Issue 7, Pages e78-e82Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1432-2277.2012.01489.x
Keywords
cytomegalovirus; ganciclovir resistance; mTOR inhibitors; solid organ transplantation
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Funding
- Ministerio de Ciencia e Innovacion, Instituto de Salud Carlos III
- European Regional Development Fund A way to achieve Europe ERDF
- Spanish Network for Research in Infectious Diseases [REIPI RD06/0008]
- Infection in Transplant Patients Study Group (GESITRA) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC)
- Institut d'Investigacio Biomedica de Bellvitge (IDIBELL), Barcelona, Spain
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Ganciclovir-resistant (GanR) cytomegalovirus (CMV) infection after organ transplantation is emerging as a significant therapeutic challenge. We report two cases of GanR CMV infection successfully managed by switching immunosuppression from calcineurin inhibitors to an mTOR inhibitor-based regimen. This salvage therapy should be considered when other options are not available.
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