Journal
TRANSPLANT INFECTIOUS DISEASE
Volume 15, Issue 6, Pages E250-E259Publisher
WILEY-BLACKWELL
DOI: 10.1111/tid.12158
Keywords
fumagillin; pediatrics; Enterocytozoon bieneusi; liver-kidney transplant; PCR; intestinal microsporidiosis
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We report the first successful use, to our knowledge, of fumagillin alone in a pediatric patient to cure intestinal microsporidiosis in a liver-kidney transplanted child. Detection of Enterocytozoon bieneusi in stool became negative from the first post-therapeutic control, while digestive symptoms disappeared in 4days. During a 9-month follow-up, polymerase chain reaction and direct examinations remained negative for microsporidia in her feces. No major undesirable effects were noted during the anti-microsporidial therapy.
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