Journal
TRANSPLANT INFECTIOUS DISEASE
Volume 15, Issue 1, Pages 22-33Publisher
WILEY
DOI: 10.1111/j.1399-3062.2012.00722.x
Keywords
hematopoietic stem cell transplantation; partially matched; cytomegalovirus infection; immune reconstitution; antigen-specific T cell
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Funding
- National Outstanding Young Scientist's Foundation of China [30725038]
- Program for Innovative Research Team in University [IRT 0702]
- Ministry of Health of China for Huang Xiao-Jun
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Cytomegalovirus (CMV) infection and delayed immune reconstitution remains a serious obstacle for successful partially matched-related donor transplantation (PMRD). We evaluated 42 patients for the development of CMV-specific CD8+ T lymphocytes (CTLCMV) following granulocyte colony-stimulating factor-primed peripheral blood (PB) and bone marrow (BM) with anti-thymocyte globulin (ATG)-based PMRD. PMRD recipients achieved a high frequency, proliferation capacity, and interferon-gamma response of CTLCMV at 1 year post transplantation. CTLCMV with the central memory CD45RO+CD62L+ cell phenotype expanded in PB and BM-resident CTLCMV displayed distinct phenotypes when CMV was reactivated. Although the incidence of CMV reactivation was high in PMRD patients (87.67%), only 11.90% of them developed CMV disease. In conclusion, after PMRD using mixed grafts with ATG-based conditioning, immune recovery to CMV seems to be early and fast, thereby reducing the incidence of CMV disease.
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