Journal
TRANSPLANT INFECTIOUS DISEASE
Volume 14, Issue 3, Pages 300-304Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1399-3062.2011.00696.x
Keywords
coccidioidomycosis; fungal infection; solid organ transplantation; transmission
Categories
Funding
- Astellas
- Merck
- Pfizer
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Coccidioidomycosis in solid organ transplant recipients most often occurs as a result of primary infection or reactivation of latent infection. Herein, we report a series of cases of transplant-related transmission of coccidioidomycosis from a single donor from a non-endemic region whose organs were transplanted to 5 different recipients. In all, 3 of the 5 recipients developed evidence of Coccidioides infection, 2 of whom had disseminated disease. The degree of T-cell immunosuppression and timing of antifungal therapy initiation likely contributed to development of disease and disease severity in these recipients. This case series highlights the importance of having a high index of suspicion for Coccidioides infection in solid organ transplant recipients, even if the donor does not have known exposure, given the difficulties of obtaining a detailed and accurate travel history from next-of-kin.
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