Journal
TRANSPLANT IMMUNOLOGY
Volume 25, Issue 4, Pages 217-220Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.trim.2011.09.002
Keywords
HLA; HLAMatchmaker; HLA antibodies; Epitope; Eplet; Nonself-self
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Two transplant candidates sensitized during pregnancy by a B*44:02 mismatch showed antibodies that reacted with an epitope defined by the 145R + 82LR eplet pair shared by all Bw4 antigens in single allele Luminex panels except B13. Both eplets are on one or more alleles of the antibody producer and according to HLAMatchmaker, they are considered intralocus and interlocus matches which should not induce antibodies. The recently developed nonself-self paradigm for HIA epitope immunogenicity has offered a ready explanation why the pair of self-145R and self-82LR eplets on B*44:02 induced specific antibodies. This finding is consistent with the concept that alloantibody responses originate from B-cells with self-HLA immunoglobulin receptors. (C) 2011 Elsevier B.V. All rights reserved.
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