Journal
TRANSLATIONAL RESEARCH
Volume 154, Issue 6, Pages 295-302Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.trsl.2009.07.010
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Funding
- National Institutes of Health (NIH) [P50 HL077101, R01 HL087871]
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Pharmacogenetics is the study of gene-drug interactions. In the post-Human Genome era, and with the realization that personal genotypes differ by millions of bases (gene polymorphisms), the application of genetics to explain interindividual differences in clinical drug response seems to offer great promise. Here, recent basic and translational developments in pharmacogenetic profiling of beta-blocker response in heart failure are reviewed in the context of the possible consequences of such advances on drug development and clinical therapeutics. (Translational Research 2009; 154:295-302)
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