Journal
TRANSLATIONAL RESEARCH
Volume 154, Issue 1, Pages 1-6Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.trsl.2009.03.007
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Funding
- NIAAA [AA015509]
- Department of Veterans Affairs
- Bly Memorial Research Fund
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Relaxin, which is a peptide hormone of the insulin superfamily, is involved in the promotion of extracellular matrix remodeling. This property is responsible for many well-known reproductive functions of relaxin. Recent important findings, including the identification of the relaxin receptor and the development of the relaxin-null mouse, have identified new targets and mechanisms for relaxin's actions, which resulted in unprecedented advances in the field. Relaxin has emerged as a natural suppressor of age-related fibrosis in many tissues, which include the skin, lung, kidney, and heart. Furthermore, relaxin has shown efficacy in the prevention and treatment of a variety of models of experimentally induced fibrosis. The intention of this review is to present a summary of recent advances in relaxin research, with a focus on areas of potential translational research on fibrosis in nonreproductive organs. (Translational Research 2009;154:1-6)
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