Journal
TRANSFUSION MEDICINE AND HEMOTHERAPY
Volume 35, Issue 3, Pages 228-238Publisher
KARGER
DOI: 10.1159/000124281
Keywords
adipose-derived stem cells; differentiation; mesenchymal stem cells
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Funding
- NIAMS NIH HHS [P01 AR050245] Funding Source: Medline
- NIA NIH HHS [R01 AG015768] Funding Source: Medline
- NIDDK NIH HHS [P30 DK072476] Funding Source: Medline
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Mesenchymal stem cells (MSCs) represent a class of multipotent progenitor cells that have been isolated from multiple tissue sites. Of these, adipose tissue and bone marrow offer advantages in terms of access, abundance, and the extent of their documentation in the literature. This review focuses on the in vitro differentiation capability of cells derived from adult human tissue. Multiple, independent studies have demonstrated that MSCs can commit to mesodermal (adipocyte, chondrocyte, hematopoietic support, myocyte, osteoblast, tenocyte), ectodermal (epithelial, glial, neural), and endodermal (hepatocyte, islet cell) lineages. The limitations and promises of these studies in the context of tissue engineering are discussed.
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