Journal
TRANSFUSION MEDICINE
Volume 28, Issue 6, Pages 433-439Publisher
WILEY
DOI: 10.1111/tme.12553
Keywords
blood donors; blood transfusion; Leishmania infantum; visceral leishmaniasis
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Funding
- Brazilian Health Surveillance Agency (ANVISA)
- National Council for Scientific and Technological Development (CNPq)
- CAPES
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Objectives This study assessed the prevalence of visceral leishmaniasis in blood donors from three endemic regions in Brazil and evaluated the risk of transmission by transfusion. Background Despite strong evidence of the transmission of visceral leishmaniasis through blood transfusion, the real risk, an essential condition for taking effective measures to control this serious disease, has not been determined. Methods A multicentre study was performed in highly endemic areas. Candidates eligible for their first blood donation underwent a socio-epidemiological interview, and blood samples were collected for enzyme-linked immunosorbent assay (ELISA) analysis, Western blot and polymerase chain reaction (PCR). Patients transfused with red blood cells or random platelet concentrates collected from these donors were also studied. The results were analysed using descriptive statistics and prevalence estimates, with significance defined as p-values Results Of the 608 eligible donors, 37 (6 center dot 1%) were positive for visceral leishmaniasis as per ELISA. The socio-epidemiological analysis showed a significantly higher prevalence in non-Caucasians (p = 0 center dot 008). Among 296 patients who received blood components from these donors, the pre-transfusion seropositivity was 7 center dot 7%, and 13 patients received blood positive for Leishmania infantum. Six patients were followed up for 90 days, of which two (33 center dot 3%) had serological conversion at 60 days. Conclusions The results confirm the high prevalence of L. infantum seropositivity among donors in the three regions; the seroconversion in a short period of time in two of six patients suggests the possibility of transmission of the infection by transfusion.
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