Journal
TRANSFUSION MEDICINE
Volume 20, Issue 3, Pages 196-199Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1365-3148.2009.00985.x
Keywords
antibody prevalence; cross-matching; red cell antigen frequency
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Red cell antibodies were identified in 11 patients [1.1%]; 2 were anti-D, 2 anti-S, 1 anti-Lea+b and 6 anti-M, 4 of which were found in non-transfused males suggesting they might be naturally acquired. The antigen frequencies found were similar to those previously published for Central Africa but 98.2% of donors were found to be Fy(a-b-). All patients tested were K negative and only three donors were found to be K positive, one being a Caucasian. Approximately 3.5% of Malawians are D negative, lower than the usual 8% quoted for Black Africans. These data confirm the assumption that pre-transfusion antibody screening is not currently required but that use of the indirect antiglobulin test in the cross-match is necessary. Haemolytic disease of the newborn (HDN) appears to be rare, or under reported, in Malawi, and more work is needed to find the real incidence of this condition.
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