Journal
TRANSFUSION AND APHERESIS SCIENCE
Volume 50, Issue 3, Pages 370-378Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.transci.2013.11.008
Keywords
Extracorporeal photochemotherapy; Dendritic cells; Platelets; Monocytes; P-selectin
Categories
Funding
- NIH-NCI [1 P50 CA121974]
- NIH Cancer Center [3 P30 CA 16359-28S1]
- NY Cardiac Foundation
- Medical Research Council [MR/J006742/1] Funding Source: researchfish
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Extracorporeal Photochemotherapy (ECP) is a widely used therapy for cutaneous T cell lymphoma (CTCL). Although the mechanism of clinical action of ECP is not precisely established, previous studies have shown evidence of induction of dendritic cells (DCs). Here we show that, under flow conditions similar to those in post-capillary venules, ECP promotes platelet immobilization and activation, initiating stepwise receptor-ligand interactions with monocytes, which then differentiate into DC. These findings clarify how ECP directly stimulates DC maturation; suggest a new clinically applicable approach to the obtainment of DC; and identify a novel mechanism that may reflect physiological induction of DC. (C) 2013 Elsevier Ltd. All rights reserved.
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