Journal
TRANSFUSION AND APHERESIS SCIENCE
Volume 49, Issue 2, Pages 318-322Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.transci.2013.08.005
Keywords
Nucleic acid testing; Blood donors; Viruses; Blood safety
Categories
Funding
- National Natural Science Foundation of China [81071348]
- Shenzhen Science and Technology Fund [201201026]
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A six-year pilot study on nucleic acid testing for HBV, HCV and HIV-1 has been undertaken on sero-negative plasmas in mini-pool and individual donation testing at Shenzhen Blood Center. Of 307,740 sero-negative blood samples, 95 of 102 HBV DNA yields were confirmed positive, 80/95 (84.2%) were classified as occult HBV infection (OBI) and 15 (15.8%) as window period cases. Amongst OBIs, 45% carried anti-HBc only, 41.3% anti-HBc and anti-HBs and 13.7% anti-HBs only. HBV DNA yield was 1:3239. One HCV WP and one HIV-1 infected donations were detected. High residual risk was found in current blood donations screening in China. (C) 2013 Elsevier Ltd. All rights reserved.
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