Journal
TRANSFUSION AND APHERESIS SCIENCE
Volume 44, Issue 1, Pages 81-91Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.transci.2010.12.013
Keywords
Rhesus; Blood group; Molecular genetics; Molecular diagnostic; Transfusion
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Funding
- Intramural NIH HHS [Z99 CL999999] Funding Source: Medline
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Rhesus is the clinically most important protein-based blood group system. It represents the largest number of antigens and the most complex genetics of the 30 known blood group systems. The RHO and RHCE genes are strongly homologous. Some genetic complexity is explained by their close chromosomal proximity and unusual orientation, with their tail ends facing each other. The antigens are expressed by the RhD and the RhCE proteins. Rhesus exemplifies the correlation of genotype and phenotype, facilitating the understanding of general genetic mechanisms. For clinical purposes, genetic diagnostics of Rhesus antigens will improve the cost-effective development of transfusion medicine. Published by Elsevier Ltd.
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