Journal
TRANSBOUNDARY AND EMERGING DISEASES
Volume 62, Issue 5, Pages E1-E10Publisher
WILEY
DOI: 10.1111/tbed.12190
Keywords
highly pathogenic porcine reproductive and respiratory syndrome virus; porcine reproductive and respiratory syndrome virus; cytokines; immunity modulation
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Funding
- National High Technology Research and Development Program of China [2011AA10A213]
- Key Technology R&D Program of Harbin [2010AA6AN083]
- Excellent Youth Foundation of Heilongjiang Province of China [JC201020]
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The CH-1a and HuN4 strains of porcine reproductive and respiratory syndrome virus (PRRSV) show different pathogenicities in pigs. To understand host immune responses against these viruses, we investigated the dynamic changes in cytokine levels produced in peripheral blood of piglets infected with the highly pathogenic PRRSV HuN4 strain or the CH-1a strain. Clinical signs, virus loads and serum cytokine levels [interferon(IFN)-, Interleukin (IL)-1, TNF-, IL-6, IL-12, IFN-, IL-10 and TGF-] were tested. The results showed that while piglets developed effective cellular immune responses against CH-1a infection, those infected with HuN4 displayed ineffective cellular immunity, organ lesions and persistent elevated levels of immunoregulatory cytokines (IL-10 and TGF-), which delayed the development of PRRSV-specific immune responses. These results demonstrated that HuN4 infection induced higher cytokine levels than that of CH-1a infection induced. The changes in inflammatory cytokines intensified the inflammatory reaction and damaged the tissues and organs.
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