Journal
TRANSBOUNDARY AND EMERGING DISEASES
Volume 58, Issue 4, Pages 305-326Publisher
WILEY
DOI: 10.1111/j.1865-1682.2011.01236.x
Keywords
foot-and-mouth; virus; pig; sheep; myocarditis; wildlife; pathogenesis; foot-and mouth disease; FMD
Categories
Funding
- Global Foot-and-Mouth Disease Research Alliance
- Agricultural Research Service
- United States Department of Agriculture
- CRIS [1940-32000-052-00D]
- Department for Environment and Rural Affairs, United Kingdom
- Biotechnology and Biological Sciences Research Council [BBS/E/I/00001442] Funding Source: researchfish
- BBSRC [BBS/E/I/00001442] Funding Source: UKRI
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Investigation into the pathogenesis of foot-and-mouth disease (FMD) has focused on the study of the disease in cattle with less emphasis on pigs, small ruminants and wildlife. 'Atypical' FMD-associated syndromes such as myocarditis, reproductive losses and chronic heat intolerance have also received little attention. Yet, all of these manifestations of FMD are reflections of distinct pathogenesis events. For example, naturally occurring porcinophilic strains and unique virus-host combinations that result in high-mortality outbreaks surely have their basis in molecular-, cellular-and tissue-level interactions between host and virus (i.e. pathogenesis). The goal of this review is to emphasize how the less commonly studied FMD syndromes and host species contribute to the overall understanding of pathogenesis and how extensive in vitro studies have contributed to our understanding of disease processes in live animals.
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