Journal
TRANSBOUNDARY AND EMERGING DISEASES
Volume 58, Issue 3, Pages 206-212Publisher
WILEY
DOI: 10.1111/j.1865-1682.2010.01197.x
Keywords
West Nile; horses; antibody; PRNT; ELISA
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Funding
- Animal Health Trust (AHT), Newmarket, UK
- Department for Environment, Food and Rural Affairs (DEFRA), UK [SE04106]
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P>West Nile virus (WNV) has re-emerged as an important pathogen for humans and horses, which are considered to be incidental 'dead-end' hosts. We have demonstrated that horses are susceptible to experimental infection with WNV and that horses infected with either WNV lineage 1 or lineage 2 elicit a similar antibody profile in serum samples. These data suggest that virus-neutralizing antibody responses persist for longer than WNV-specific IgM levels in serum and that there are not any notable differences in the antibody profile following experimental infection of horses with either WNV lineage 1 and lineage 2 viruses. Furthermore, the duration of IgM appears to be short-lived in horses and may be useful for identifying and differentiating recent infections from previously exposed animals.
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