Journal
PROTEIN & CELL
Volume 6, Issue 10, Pages 722-734Publisher
OXFORD UNIV PRESS
DOI: 10.1007/s13238-015-0195-8
Keywords
autophagy; Atg7; mouse model; development; disease
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Funding
- National Institutes of Health (NIH) Intramural Program
- Leducq Foundation
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Macroautophagy is an evolutionarily conserved intracellular degradation system used by life ranging from yeasts to mammals. The core autophagic machinery is composed of ATG (autophagy-related) protein constituents. One particular member of the ATG protein family, Atg7, has been the focus of recent research. Atg7 acts as an E1-like activating enzyme facilitating both microtubule-associated protein light chain 3 (LC3)-phosphatidylethanolamine and ATG12 conjugation. Thus, Atg7 stands at the hub of these two ubiquitin-like systems involving LC3 and Atg12 in autophagic vesicle expansion. In this review, I focus on the pleiotropic function of Atg7 in development, maintenance of health, and alternations of such control in disease.
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