Journal
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
Volume 103, Issue 3, Pages 213-214Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.trstmh.2008.08.013
Keywords
African trypanosomiasis; Sleeping sickness; Central nervous system; Cytokines; Encephalitis; Inflammation
Funding
- The Wellcome Trust
- Sir Jules Thorne Charitable Trust
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The late, or encephalitic, stage of human African trypanosomiasis (HAT), or sleeping sickness, is typified by a diffuse meningoencephalitis characterised neuropathologically by perivascular infiltration of inflammatory cells. While the cause of this neuroinflammatory reaction is not understood, there is evidence for the roles of pro-inflammatory cytokines such as IFN-gamma and TNF-alpha and counter-inflammatory cytokines such as IL-10, with the balance of these influencing disease outcome. Because of the practical difficulties of obtaining serial measurements in patients, it has proved difficult to assign either cause or effect properties to measured cytokines, but mechanistic animal modelling studies are proving helpful. (C) 2008 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.
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