Journal
TRANSACTIONS OF NONFERROUS METALS SOCIETY OF CHINA
Volume 19, Issue 5, Pages 1232-1236Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S1003-6326(08)60434-3
Keywords
magnetism; chitosan; 5-fluorouracil; nano-particle; drug release
Categories
Funding
- National Natural Science Foundation of China [30572455, 30670990]
- Postdoctor Foundation of China [20060390891]
- Ministry of Education of China [NCET-06-0685]
- Science and Technology of Hunan Province, China [2006FJ4243]
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In order to synthesize the targeting drug carrier system, magnetic chitosan-5-fluorouracil nano-particles were prepared by using 5-fluorouracil (5-Fu) as model drug, Fe3O4 nano-particles as kernel, chitosan as enveloping material and glutaraldehyde as cross linking agent through ultrasonic technique. The morphology of the magnetic chitosan-5-Fu nano-particles was observed with a transmission electron microscope(TEM). The results showed that magnetic chitosan-5-Fu nano-particles were prepared in spherical structure with a size range of 50-60 nm. The delivering capacity and drug releasing properties of magnetic chitosan-5-Fu nano-particles were investigated by UV-vis spectrum analysis. The results showed that the loading capacity was 13.4% and the cumulative release percentage in the phosphate buffer (pH=7.2) solutions was 68% in 30 h. These data indicate that the wrapped drug of magnetic chitosan-5-Fu nano-particles was slowly-re I eased. The magnetic response of magnetic chitosan-5-Fu nano-particles was studied by UV-vis spectrometer to detect the changes of solution absorbance. Without external magnetic field, the nano-particle deposition rate was slow. When being subjected to 8 mT magnetic field, the particle sedimentation rate was increased rapidly. The results showed that magnetic chitosan-5-Fu nano-particles have a magnetic stability and strong targeting characteristics.
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